Balancing Enzyme Encapsulation Efficiency and Stability in Complex Coacervate Core Micelles
نویسندگان
چکیده
منابع مشابه
Complex coacervate core micelles as diffusional nanoprobes.
Because of their ease of preparation and versatile modification opportunities, complex coacervate core micelles (C3Ms) may be a good alternative for expensive diffusional probes, such as dendrimers. However, C3Ms are unstable at high salt concentrations and may fall apart in contact with other polymers or (solid) materials. Therefore, we designed and characterized small (15 nm radius), stable f...
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Encapsulation of proteins can be beneficial for food and biomedical applications. To study their biophysical properties in complex coacervate core micelles (C3Ms), we previously encapsulated enhanced green fluorescent protein (EGFP) and its monomeric variant, mEGFP, with the cationic-neutral diblock copolymer poly(2-methyl-vinyl-pyridinium)n-b-poly(ethylene-oxide)m (P2MVPn-b-PEOm) as enveloping...
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We have studied the formation and the stability of grafted block complex coacervate core micelles (C3Ms) in solution and the influence of grafted block C3M coatings on the adsorption of the proteins beta-lactoglobulin, bovine serum albumin, and lysozyme. The C3Ms consist of a grafted block copolymer PAA(21)-b-PAPEO(14) (poly(acrylic acid)-b-poly(acrylate methoxy poly(ethylene oxide)), with a ne...
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This article presents a facile strategy to combine Eu(3+) and Gd(3+) ions into coacervate core micelles in a controlled way with a statistical distribution of the ions. Consequently, the formed micelles show a high tunability between luminescence and relaxivity. These highly stable micelles present great potential for new materials, e.g. as bimodal imaging probes.
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We study the long term (steady state) performance of a simple, randomized, local load balancing technique. We assume a system of n processors connected by an arbitrary network topology. Jobs are placed in the processors by a deterministic or randomized adversary. The adversary knows the current and past load distribution in the network and can use this information to place the new tasks in the ...
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ژورنال
عنوان ژورنال: Langmuir
سال: 2020
ISSN: 0743-7463,1520-5827
DOI: 10.1021/acs.langmuir.0c01073